39P Longitudinal increases in albumin-adjusted serum calcium predict ovarian cancer

BackgroundScreening methods for ovarian cancer are urgently needed. Previously, we showed that women who develop show an increase in serum calcium and a decrease albumin (Schwartz et al, 2020, Gynecol Oncol 2020:159:264-269). These changes could be useful screening. We asked, prior to their diagnosis, with more likely positive slope albumin-adjusted (a-asc)?MethodsThis is population-based case-control study based Sioux Falls, SD. Cases were epithelial cancer. Controls without diagnosis of Patients history and/or parathyroid disease excluded. Data from patients’ Comprehensive Metabolic Panels (CMPs). calculated (a-asc) estimated regression equations each woman’s a-asc pre-diagnosis diagnosis. analyzed by multiple regression, ANCOVA logistic regression.ResultsWe studied 124 cases 98 controls. significantly older than controls (64.7 12.9 SD, vs. 41.0 16.8 years). For controls, the first last was 9.23 mg/dL, 0. cases, values 9.28 9.37 0.04 mg/dl per year (P<0.001). The probability mg/dL/year increased age until 70 significant dose-response. Odd Ratio (OR) 65 yr old woman 0.06 mg/dL increase/year ∼3.0; OR 1 ∼10. This effect also seen early stage tumors persisted after age-adjustment.ConclusionsIn health, levels tightly regulated “expected” zero. A cancer, if confirmed future studies, suggests help identify undiagnosed Increases often small easily overlooked. However, computer algorithm calculate annual records. Women rising candidates medical surveillance (e.g., transvaginal ultrasonography).Legal entity responsible studyThe authors.FundingThis research funded grants University North Dakota School Medicine & Health Sciences, Great Plains IDeA-CTR Coverys Community HealthCare Foundation (to GGS).DisclosureAll authors have declared no conflicts interest. (a-asc)? Screening MethodsThis regression. ResultsWe age-adjustment. ConclusionsIn ultrasonography). In